The immune surveillance theory of cancer posits that the body’s immune system detects and destroys randomly occurring malignant cells. This theory is based on the observation of the increased frequency of malignancies in primary and secondary immunodeficiencies, and is supported by the successful demonstration of immune augmentation in current oncological immune therapy approaches. This article reviews this model in the context of Down syndrome (DS), a condition with a unique tumor profile and various immune defects.
Source: Daniel Satge and Markus G. Seidel