Individuals with Down syndrome may be more susceptible to liver fibrosis because some conditions that contribute to or cause liver fibrosis are more common in people with Down syndrome. These include fatty liver, autoimmune liver disease, and celiac disease. Other conditions that can cause liver disease include chronic alcohol consumption, viral hepatitis, schistosomiasis (a parasitic infection that is caused by a flatworm that is not found in the United States), and chronic use of medications that affect the liver.
Source: Advocate Medical Group Adult Down Syndrome Center