Patients with Down syndrome (DS) appear to be at a greater risk for serious infections, but it is unclear whether this is due to anatomic variations or intrinsic immune defects. Immune evaluation and vaccine responses in Down syndrome Source: US National Library of Medicine National Institutes of Health Tags:b-cellscellular immunityDown syndromehumoral immunityimmuneimmunityimmunodeficiencyimmunoglobulininfectionst-cellsvaccinevaccines