Recent advancements in single-cell multi-omics technologies have provided unprecedented insights into the cellular and molecular heterogeneity of DS-associated hematologic neoplasms. Hematologic Neoplasms Associated with Down Syndrome Cellular and Molecular Heterogeneity of the Diseases Source: Peroni et al. Tags:acute lymphoblastic leukemiaacute megakaryoblastic leukemiaacute myeloid leukemiaALLALL-DScytogenetic abnormalitiesDown syndromeDSepigenetic alterationshematological malignanciesleukemiaML-DSmulti-omics approachnon-DS leukemogenesisoncogenic mutationspersonalized medicinesingle-cell RNA sequencingtransient abnormal myelopoiesistrisomy 21
