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Health and Research – Cognition/Development

Executive Function in Adolescents with Down Syndrome

By November 16, 2020December 20th, 2023No Comments

The results suggest a broad impairment in EF in adolescents with DS, and are consistent with several similar studies conducted with adults with DS. We assume that EF deficit is a characteristic of DS.

Executive function in adolescents with Down Syndrome

First published: 20 March 2010
https://doi.org/10.1111/j.1365-2788.2010.01262.x
Citations: 209

Abstract

Background  The present work is aimed at analysing executive function (EF) in adolescents with Down Syndrome (DS). So far, EF has been analysed mainly in adults with DS, showing a pattern of impairment. However, less is known about children and adolescents with this syndrome. Studying adolescents with DS might help us better understand whether performances on EF tasks of individuals with DS are determined by age or by Alzheimer disease, as some studies suggest, or whether their performances are directly related to DS cognitive profile.

Method  A battery of EF tasks assessing set shifting, planning/problem-solving, working memory, inhibition/perseveration and fluency, as well as a tasks assessing sustained attention has been administered to a group of 15 adolescents with DS and 15 typically developing children matched for mental age. All EF tasks were selected from previous studies with individuals with intellectual disabilities or from developmental literature and are thought to be useful for the samples considered.

Results  The present results revealed that the group of individuals with DS performed at a significantly lower level on tasks assessing set shifting, planning/problem-solving, working memory and inhibition/perseveration, but not on the tasks assessing fluency. In addition, individuals with DS demonstrated a greater number of errors and less strategy use for the sustained attention task.

Conclusions  The results suggest a broad impairment in EF in adolescents with DS, and are consistent with several similar studies conducted with adults with DS. We assume that EF deficit is a characteristic of DS.

 

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  • Laura del Hoyo Soriano, Tracie C. Rosser, Debra R. Hamilton, Danielle J. Harvey, Leonard Abbeduto, Stephanie L. Sherman, Relationship between Apgar scores and long-term cognitive outcomes in individuals with Down syndrome, Scientific Reports, 10.1038/s41598-021-90651-3, 11, 1, (2021).
  • Silvia Lanfranchi, Sara Onnivello, Maristella Lunardon, Francesco Sella, Marco Zorzi, Parent-based training of basic number skills in children with Down syndrome using an adaptive computer game, Research in Developmental Disabilities, 10.1016/j.ridd.2021.103919, 112, (103919), (2021).
  • Martina Fontana, Maria Carmen Usai, Enrico Toffalini, Maria Chiara Passolunghi, Meta-analysis on inhibition from childhood to young adulthood in people with Down syndrome, Research in Developmental Disabilities, 10.1016/j.ridd.2020.103838, 109, (103838), (2021).
  • Andrew S. Tungate, Frances A. Conners, Executive function in Down syndrome: A meta-analysis, Research in Developmental Disabilities, 10.1016/j.ridd.2020.103802, 108, (103802), (2021).
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  • Karolina Maciejewska, Kamila Czarnecka, Paweł Szymański, A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease, Pharmacological Reports, 10.1007/s43440-021-00293-5, 73, 6, (1565-1581), (2021).
  • Audrey Landuran, Clélia Raynaud, Bernard N’kaoua, Cognitive and Motor Skills of People with Down Syndrome According to Their Perceived Self-Determination, Journal of Developmental and Physical Disabilities, 10.1007/s10882-021-09791-z, 34, 1, (89-111), (2021).
  • Ming-Chih Sung, Byungmo Ku, Willie Leung, Megan MacDonald, The Effect of Physical Activity Interventions on Executive Function Among People with Neurodevelopmental Disorders: A Meta-Analysis, Journal of Autism and Developmental Disorders, 10.1007/s10803-021-05009-5, 52, 3, (1030-1050), (2021).
  • Nieves Valencia Naranjo, María Auxiliadora Robles-Bello, Dynamic Assessment in Preschoolers with Down Syndrome and Nonspecific Intellectual Disability, Psicología Educativa, 10.5093/psed2020a9, (000-000), (2020).
  • Giovanni Mento, Gaia Scerif, Umberto Granziol, Malida Franzoi, Silvia Lanfranchi, The Effect of Probabilistic Context on Implicit Temporal Expectations in Down Syndrome, Frontiers in Psychology, 10.3389/fpsyg.2020.00369, 11, (2020).
  • Maria Chiara Di Lieto, Emanuela Castro, Chiara Pecini, Emanuela Inguaggiato, Francesca Cecchi, Paolo Dario, Giovanni Cioni, Giuseppina Sgandurra, Improving Executive Functions at School in Children With Special Needs by Educational Robotics, Frontiers in Psychology, 10.3389/fpsyg.2019.02813, 10, (2020).
  • Zachary M. Himmelberger, Edward C. Merrill, Frances A. Conners, Beverly Roskos, Yingying Yang, Trent Robinson, The Acquisition of Survey Knowledge by Individuals With Down Syndrome, Frontiers in Human Neuroscience, 10.3389/fnhum.2020.00256, 14, (2020).
  • Martina Penke, Eva Wimmer, Verbal short-term memory and sentence comprehension in German children and adolescents with Down syndrome: Beware of the task, First Language, 10.1177/0142723719899587, (014272371989958), (2020).
  • E. K. Schworer, D. J. Fidler, M. Kaur, A. W. Needham, M. A. Prince, L. A. Daunhauer, Goal‐directed action planning in infants with Down syndrome, Journal of Intellectual Disability Research, 10.1111/jir.12763, 64, 9, (713-724), (2020).
  • L. Palmqvist, H. Danielsson, A. Jönsson, J. Rönnberg, Cognitive abilities and life experience in everyday planning in adolescents with intellectual disabilities: Support for the difference model, Journal of Intellectual Disability Research, 10.1111/jir.12710, 64, 3, (209-220), (2020).
  • Lydie Iralde, Arnaud Roy, Juliette Detroy, Philippe Allain, A Representational Approach to Executive Function Impairments in Young Adults with Down Syndrome, Developmental Neuropsychology, 10.1080/87565641.2020.1797043, 45, 5, (263-278), (2020).
  • Manisha Udhnani, Megan Perez, Liv S. Clasen, Elizabeth Adeyemi, Nancy Raitano Lee, Relations between Everyday Executive Functioning and Language in Youth with Down Syndrome and Youth with Autism Spectrum Disorder, Developmental Neuropsychology, 10.1080/87565641.2019.1706518, (1-15), (2020).
  • Audrey Landuran, Bernard N’Kaoua, Prospective memory in adults with down syndrome, Applied Neuropsychology: Adult, 10.1080/23279095.2020.1828082, (1-12), (2020).
  • Julia B. Barrón-Martínez, Natalia Arias-Trejo, Perceptual similarity effect in people with Down syndrome, International Journal of Developmental Disabilities, 10.1080/20473869.2020.1729016, 68, 2, (182-189), (2020).
  • Francesca Antonaros, Veronica Ghini, Francesca Pulina, Giuseppe Ramacieri, Elena Cicchini, Elisa Mannini, Anna Martelli, Agnese Feliciello, Silvia Lanfranchi, Sara Onnivello, Renzo Vianello, Chiara Locatelli, Guido Cocchi, Maria Chiara Pelleri, Lorenza Vitale, Pierluigi Strippoli, Claudio Luchinat, Paola Turano, Allison Piovesan, Maria Caracausi, Plasma metabolome and cognitive skills in Down syndrome, Scientific Reports, 10.1038/s41598-020-67195-z, 10, 1, (2020).
  • Nancy Raitano Lee, Amritha Nayak, M. Okan Irfanoglu, Neda Sadeghi, Catherine J. Stoodley, Elizabeth Adeyemi, Liv S. Clasen, Carlo Pierpaoli, Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry, Scientific Reports, 10.1038/s41598-020-61799-1, 10, 1, (2020).
  • Camila Sabat, Paulina Arango, Marc J. Tassé, Marcela Tenorio, Different abilities needed at home and school: The relation between executive function and adaptive behaviour in adolescents with Down syndrome, Scientific Reports, 10.1038/s41598-020-58409-5, 10, 1, (2020).
  • Y. Shishido, E.M. Mahone, L.A. Jacobson, Investigation of the Clinical Utility of the BRIEF2 in Youth With and Without Intellectual Disability, Journal of the International Neuropsychological Society, 10.1017/S1355617720000636, (1-9), (2020).
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  • Kandianos Emmanouil Sakalidis, Jan Burns, Debbie Van Biesen, Waleed Dreegia, Florentina Johanna Hettinga, The Impact of Cognitive Functions and Intellectual Impairment on Pacing and Performance in Sports, Psychology of Sport and Exercise, 10.1016/j.psychsport.2020.101840, (101840), (2020).
  • Fiorenza Stagni, Andrea Giacomini, Marco Emili, Beatrice Uguagliati, Maria Paola Bonasoni, Renata Bartesaghi, Sandra Guidi, Neuroanatomical alterations in higher-order thalamic nuclei of fetuses with Down syndrome, Clinical Neurology and Neurosurgery, 10.1016/j.clineuro.2020.105870, 194, (105870), (2020).
  • Pishan Chang, Daniel Bush, Stephanie Schorge, Mark Good, Tara Canonica, Nathanael Shing, Suzanna Noy, Frances K. Wiseman, Neil Burgess, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher, Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome, Cell Reports, 10.1016/j.celrep.2019.12.065, 30, 4, (1152-1163.e4), (2020).
  • María Martínez de Lagrán, Mapping behavioral landscapes in Down syndrome animal models, 10.1016/bs.pbr.2020.01.005, (2020).
  • Lina R. Patel, Anna J. Esbensen, Elise M. Sannar, Defining behavioral challenges in Down syndrome utilizing a multidimensional dynamic approach: Implications for treatment intervention, 10.1016/bs.irrdd.2020.07.004, (2020).
  • Laura Reiche, Patrick Küry, Peter Göttle, Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis?, Cells, 10.3390/cells8121591, 8, 12, (1591), (2019).
  • Carla M. Startin, Bryony Lowe, Sarah Hamburg, Rosalyn Hithersay, Andre Strydom, Validating the Cognitive Scale for Down Syndrome (CS-DS) to Detect Longitudinal Cognitive Decline in Adults With Down Syndrome, Frontiers in Psychiatry, 10.3389/fpsyt.2019.00158, 10, (2019).
  • Elizabeth Smith, Craig Hedge, Christopher Jarrold, A Novel Framework to Measure Executive Function in Down Syndrome With Applications for Early Clinical Diagnosis of Dementia, American Journal on Intellectual and Developmental Disabilities, 10.1352/1944-7558-124.4.354, 124, 4, (354-373), (2019).
  • Anna J. Esbensen, Emily K. Hoffman, Rebecca Shaffer, Elizabeth Chen, Lina Patel, Lisa Jacola, Reliability of Informant-Report Measures of Executive Functioning in Children With Down Syndrome, American Journal on Intellectual and Developmental Disabilities, 10.1352/1944-7558-124.3.220, 124, 3, (220-233), (2019).
  • E. McGlinchey, M. McCarron, A. Holland, P. McCallion, Examining the effects of computerised cognitive training on levels of executive function in adults with Down syndrome, Journal of Intellectual Disability Research, 10.1111/jir.12626, 63, 9, (1137-1150), (2019).
  • Gerd Schmitz, Jakob M. Meis, Matthias Hafferkamp, Sabine Schmitz, Competencies for rating perceived exertion in amateur soccer players with and without intellectual disabilities, Journal of Applied Research in Intellectual Disabilities, 10.1111/jar.12668, 33, 2, (248-257), (2019).
  • Giovanni Mento, Gaia Scerif, Umberto Granziol, Malida Franzoi, Silvia Lanfranchi, Dissociating top-down and bottom-up temporal attention in Down syndrome: A neurocostructive perspective, Cognitive Development, 10.1016/j.cogdev.2018.12.004, 49, (81-93), (2019).
  • Marianna Alesi, Giuseppe Battaglia, Motor development and Down syndrome, International Review of Research in Developmental Disabilities – State of the Art of Research on Down Syndrome, 10.1016/bs.irrdd.2019.06.007, (169-211), (2019).
  • Sara Onnivello, Silvia Lanfranchi, Marco Zorzi, Mathematical abilities in Down syndrome, International Review of Research in Developmental Disabilities – State of the Art of Research on Down Syndrome, 10.1016/bs.irrdd.2019.06.005, (257-291), (2019).
  • Maja Roch, Laura Mattera, Eleonora Simion, Reading for comprehension: the contribution of decoding, linguistic and cognitive skills, International Review of Research in Developmental Disabilities – State of the Art of Research on Down Syndrome, 10.1016/bs.irrdd.2019.06.004, (213-255), (2019).
  • Francesca Pulina, Renzo Vianello, Silvia Lanfranchi, Cognitive profiles in individuals with Down syndrome, International Review of Research in Developmental Disabilities – State of the Art of Research on Down Syndrome, 10.1016/bs.irrdd.2019.06.002, (67-92), (2019).
  • Angela F. Lukowski, Helen M. Milojevich, Lauren Eales, Cognitive Functioning in Children with Down Syndrome: Current Knowledge and Future Directions, 10.1016/bs.acdb.2019.01.002, (257-289), (2019).
  • Michael S. Rafii, Alexander M. Kleschevnikov, Mariko Sawa, William C. Mobley, Down syndrome, Geriatric Neurology, 10.1016/B978-0-12-804766-8.00017-0, (321-336), (2019).
  • Mª Auxiliadora Robles-Bello, Nieves Valencia-Naranjo, David Sánchez-Teruel, Learning Potential is Useful in Pre-schoolers with Fragile X and Down Syndrome, Psicología Educativa, 10.5093/psed2018a8, 2018avonline, 2, (1-7), (2018).
  • Ines Basten, Richard Boada, Hudson Taylor, Katherine Koenig, Veridiana Barrionuevo, Ana Brandão, Alberto Costa, On the Design of Broad-Based Neuropsychological Test Batteries to Assess the Cognitive Abilities of Individuals with Down Syndrome in the Context of Clinical Trials, Brain Sciences, 10.3390/brainsci8120205, 8, 12, (205), (2018).
  • Laura Traverso, Martina Fontana, Maria Carmen Usai, Maria C. Passolunghi, Response Inhibition and Interference Suppression in Individuals With Down Syndrome Compared to Typically Developing Children, Frontiers in Psychology, 10.3389/fpsyg.2018.00660, 9, (2018).
  • Jacqueline Vásquez-Navarrete, Agustín D. Martínez, Stéphane Ory, Ximena Baéz-Matus, Arlek M. González-Jamett, Sebastián Brauchi, Pablo Caviedes, Ana M. Cárdenas, RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndrome, Frontiers in Cellular Neuroscience, 10.3389/fncel.2018.00189, 12, (2018).
  • Antonio Silva Cunha, Antonio Carlos Silva-Filho, Carlos José Dias, Rafael Durans, Janaína de Oliveira Brito-Monzani, Bruno Rodrigues, Cristiano Teixeira Mostarda, Impacts of low or vigorous levels of physical activity on body composition, hemodynamics and autonomic modulation in Down syndrome subjects, Motriz: Revista de Educação Física, 10.1590/s1980-6574201800010013, 24, 1, (2018).
  • Koviljka Barisnikov, Fleur Lejeune, Social knowledge and social reasoning abilities in a neurotypical population and in children with Down syndrome, PLOS ONE, 10.1371/journal.pone.0200932, 13, 7, (e0200932), (2018).
  • Mary Godfrey, Nancy Raitano Lee, Memory profiles in Down syndrome across development: a review of memory abilities through the lifespan, Journal of Neurodevelopmental Disorders, 10.1186/s11689-017-9220-y, 10, 1, (2018).
  • K. E. Biesmans, L. Aken, E. M. J. Frunt, P. A. M. Wingbermühle, J. I. M. Egger, Inhibition, shifting and updating in relation to psychometric intelligence across ability groups in the psychiatric population, Journal of Intellectual Disability Research, 10.1111/jir.12559, 63, 2, (149-160), (2018).
  • A. J. Esbensen, E. K. Hoffman, Impact of sleep on executive functioning in school‐age children with Down syndrome, Journal of Intellectual Disability Research, 10.1111/jir.12496, 62, 6, (569-580), (2018).
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Source: Europe PMC

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