We recently received a question about the use of Depo-Provera. Depo-Provera is an injection of progesterone that is used to: Prevent pregnancy Reduce periods and/or symptoms from periods. Source: Advocate Medical Group Adult Down Syndrome Center Tags:birth controlbirth control injectioncontraceptivesfemalefemale healthfemalesmenstrual cyclemenstruationperiodsrelationshipssexual healthWomen's health